Search results for "Van’t hoff enthalpy"

Biophysical Characterization of Polysialic Acid—Membrane Nanosystems

2019

Polysialic acid (polySia) is a long, membrane-bound, polyanionic polymer (with the degree of polymerization, DP, up to 400) of negatively charged sialic acid monomers. Biological roles of polySia are based on its ability to modulate repulsive and attractive interactions, and its ability to modulate membrane surface charge density, pH at the membrane surface, and membrane potentials. PolySia is used in anti-bacterial and anti-cancer therapies, and in neural tissue repair. Hydrophobically-modified polySia chains can form nano-structures (micelles or liposomes) with high stability and low toxicity for drug delivery. The analysis, based on the Goldman-Hodgkin-Katz equation, of transmembrane pot…